Oku-sama wa Mahō Shōjo: Bewitched Agnes is produced by Media Factory, J.C. Staff, and Amber Film Works. It was directed by Hiroshi Nishikiori, with character designs by Shinya Hasegawa and art direction by Chikako Shibata. The opening theme is "Home & Away" (ホーム&アウェイ) by Melocure and the ending theme is "Jewelry" by Kikuko Inoue. The series was initially broadcast in Japan in thirteen episodes between 4 July 2005 and 25 September 2005 on several television channels: Chiba TV, Kids Station, Sun TV, TV Aichi, TV Kanagawa, and TV Saitama.
The viewer meets Ureshiko Asaba, who is currently cleaning a room in the boarding house where she is staying, because a new tenant is on the way. In order to make the job go more quickly, Ureshiko tries to use her magic power, only to overdo it and make a mess.
Later that day, a new girl transfers into the local middle school for the summer term. After classes end, she reveals that she also possesses magic power, and begins to transform the school into one she finds more attractive. Before she can complete the job, Ureshiko in the form of Agnes Bell reverts the school. The second girl identifies herself as Cruje, the next Manager of the Wonderland, and demands that Agnes hand over the Managerial Ring, but Agnes immediately refuses.
About this time, Tatsumi Kagura and Yuuko Ayase are driving through the town on their way to the boarding house—Tatsumi is to be the new tenant. The pair almost get into an accident, but they are saved by Agnes's magic. Tatsumi and Yuuko then continue on to the boarding house, only to find that the assistant manager looks just like the woman who saved them.
Nori and Ururu are introduced as Ureshiko's childhood friends, who tell her to fight Cruje to protect the Wonderland. Tatsumi begins his work at a publishing company, and starts his first assignment—to secure the rights to local author Tamotsu Asaba's new book.