List of NFL quarterbacks who have passed for 400 or more yards in a game

In the National Football League (NFL), 130 different quarterbacks have passed for at least 400 yards in a single game: 309 times in the regular season and 20 more in the postseason. Sid Luckman was the first to pass for 400 yards, in 1943. Drew Brees has recorded the most 400-yard games, with 18 in total. Brees has also recorded the most 400-yard postseason games, with 3, including 2 consecutive in a single postseason (unofficial 3 consecutive over two postseasons). Cam Newton is the only player to throw for 400 yards in his first career game, and the only rookie with two (coincidentally consecutive) 400 yard games. Don Strock is the only quarterback to have thrown for 400 yards in a game that he did not start. Kurt Warner and Tom Brady are the only two quarterbacks to have thrown a 400-yard game in the Super Bowl.

There have been nine occurrences of a quarterback recording two consecutive 400-yard games. There have been 13 games where two opposing quarterbacks collected 400 passing yards in the same game. There have been four single-days (September 21, 1986, January 1, 2012, October 26, 2014, and October 18, 2015) where three quarterbacks recorded 400-yard games. There has been one NFL week (September 8–12, 2012) where four quarterbacks recorded 400-yard games.

Ken O'Brien and Nick Foles are the only quarterbacks to have earned a perfect 158.3 passer rating in a 400-yard game. Including O'Brien's and Foles' perfect passer rating games, there have been 13 times a quarterback earned a rating of 140 or higher in their 400-yard games—all were wins. Peyton Manning has the highest passer rating in a 400-yard postseason game, with 145.7. Randall Cunningham has the two lowest passer ratings in 400-yard games, losing both his 50.5 and his 52.0 rated games.

Sixteen quarterbacks have thrown one game each of at least 500 yards, with only two players having two, Ben Roethlisberger and Drew Brees. Four of these quarterbacks never threw another 400-yard game. Y.A. Tittle had the highest passer rating, 151.4, for a 500-yard game—also tying the NFL record of 7 touchdown passes in that effort.

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