List of Major League Baseball single-game home run leaders

Writers of Sporting News described hitting four home runs in a single Major League Baseball (MLB) game as "baseball's greatest single-game accomplishment". 16 players have accomplished the feat to date, the most recent being Josh Hamilton of the Texas Rangers on May 8, 2012. No player has done this more than once in his career and no player has ever hit more than four in a game. Bobby Lowe was the first to hit four home runs in a single game, doing so on May 30, 1894. Fans were reportedly so excited that they threw $160 in silver coins ($4,400 today) onto the field after his fourth home run.

These games have resulted in other MLB single-game records due to the extreme offensive performance. Mark Whiten, for example, tied Jim Bottomley for the most runs batted in in a single game with 12 in his four-homer game.Shawn Green hit a double and a single along with his four home runs for 19 total bases, an MLB record. It surpassed Joe Adcock's mark of 18, which also came from a four-homer game.

Chuck Klein, Pat Seerey, and Mike Schmidt each hit their four in a game that went into extra innings. Four home runs generate significant offense which generally allows a team to win, although Ed Delahanty's and Bob Horner's teams lost their respective milestone games.

Carlos Delgado was the only one who hit his four home runs in a game in which he made only four plate appearances.

Warren Spahn pitched the ball which Gil Hodges hit for the first of his four, the only Hall of Fame pitcher faced during a four-home-run game. Hodges and Adcock are the only players to hit home runs against four different pitchers in one game. Lowe and Delahanty, on the other hand, are the only players to hit four home runs in one game against just one pitcher: Ice Box Chamberlain and Adonis Terry respectively.

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