The Kissxsis manga, written and illustrated by Bow Ditama, is an ongoing seinen publication that premiered as a one-shot in the January 2004 issue of Bessatsu Young Magazine, a bimonthly periodical circulated by Kodansha. The story, a comedic slice of life, centers on Keita Suminoe, a fifteen-year-old middle-turn-high school student who is the frequent subject of his sixteen-year-old stepsisters' romantic attention.
After being met with largely positive reception from readers, the strip was given regular syndication in December 2005, going on to become a monthly series when Kodansha changed the frequency of its magazine, renamed Young Magazine, on December 9, 2009. News of work to redevelop Kiss×Sis into an animated series first surfaced in the June 2008 issue of Bessatsu Young Magazine; since then, the series has been made into a twelve-episode television show broadcast on AT-X from April 5 to June 21, 2010, and an ongoing direct-to-video (OVA) release started December 22, 2008, both produced by Feel.
Kiss×Sis was first collected into a volume on September 6, 2007, by Kodansha under their KC Deluxe imprint, and has been published into a current twelve volumes. Following the release of the second volume, limited edition bundles of the manga and direct-to-video releases of the anime began to be offered. In addition to its domestic release, the manga is also licensed for distribution in Taiwan by Sharp Point Press.