List of Hot 100 number-one singles of 1980 (U.S.)

These are the Billboard Hot 100 number-one singles of 1980. The two longest running number-one singles of 1980 are "Call Me" by Blondie and "Lady" by Kenny Rogers with each single obtaining six weeks on top of the chart. Every song that went to number one for 1980 stayed on the Billboard Hot 100 over twenty weeks.

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