List of Billboard Hot 100 number-one singles of 2008

The Billboard Hot 100 is a chart that ranks the best-performing singles of the United States. Published by Billboard magazine, the data is compiled by Nielsen SoundScan based collectively on each single's weekly physical and digital sales, and airplay. In 2008, there were 14 singles that topped the chart in 52 issues of the magazine.

Rapper Flo Rida's "Low" was the first number one of the year, and the longest-running single in 2008, staying at number one for 10 consecutive weeks. It is the longest stay at the top for a single since R&B singer Beyoncé's "Irreplaceable" reigned for 10 straight weeks starting in late 2006. "Low" is the best-performing single of 2008 in the United States, ranking number one on Billboard's year end chart of the Top Hot 100 Hits of 2008. Other singles with extended runs at number one include Katy Perry's "I Kissed a Girl", which stayed at the top spot for seven straight weeks, and T.I.'s "Whatever You Like", which topped the chart for seven non-consecutive weeks.

In 2008, seven acts gained their first U.S. number-one single: Flo Rida, Leona Lewis, Lil Wayne, Coldplay, and Perry, all of whom were lead artists, and Young Jeezy and Static Major as featured guests. T.I. earned his first number-one single as lead artist with "Whatever You Like". He also had the most weeks on top with 13, combining his two singles "Whatever You Like" and "Live Your Life", the latter of which charted at number one for six non-consecutive weeks. Artists to have multiple number one hits during the year were Rihanna with three, (one of those as a featured artist credit in "Live Your Life"), and T.I. with two. Rihanna spent the most time of any female at the top, spending nine non-consecutive weeks at number one on three different songs.

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