List of Billboard Hot 100 number-one singles of 1981

These are the Billboard Hot 100 number-one hits of 1981. The longest running number-one single of 1981 is "Physical" by Olivia Newton-John which stayed at the top of the chart for six weeks in 1981 and then for four additional weeks in 1982, with a total of ten weeks at number-one. This also makes "Physical" the longest running number-one single of the 1980s.

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