List of Big Brother 5 (U.S.) HouseGuests

The fifth edition of the American reality series Big Brother featured a total of 14 house guests, and aired in the summer of 2004.

Adria Klein (born 1974 in Birmingham, Alabama), 42, was a fitness professional from Birmingham, Alabama. Adria was a part of the "Twin Twist" of Project DNA, in which she would frequently trade spots in the house with her twin sister, Natalie, who played as Adria. The two had the goal of making to the fifth week, and if they succeeded, Natalie would enter the game as an individual. The group went on to complete the task, and Natalie entered the house. Adria was a part of the girls alliance with Diane, Nakomis, Karen, Lori, Natalie and Will, though also had close friendships with Michael and Drew. Marvin often referred to her as "Big Bootylicious" due to the size of her , a joke that lasted during her stay in the house. Adria was first nominated for eviction on Day 25, as a replacement nominee for ally Nakomis. Despite attempts to evict her, she ultimately survived the eviction. She was the sixth Head of Household of the season, and made the decision to turn on her alliance and nominate Will and Marvin for eviction. She also won the Power of Veto that week, and chose to leave her nominations intact, resulting in Will's eviction. The following week, Adria was nominated alongside Natalie, but she won her second consecutive Power of Veto and saved herself from the block. Natalie was evicted that week. Adria was nominated for a second time the following week, and was evicted on Day 63 after failing to win the Power of Veto. Adria came in seventh place. She was the third member of the Jury and voted for Michael to win.

Diane Nicole Henry (born 1982 in Euless, Texas), 34, was a cocktail waitress from Burlington, Kentucky. She is the first HouseGuest to helm from Kentucky in Big Brother history. Diane revealed that she has a twin sister, Lindsay, outside of the house. Diane was a part of the girls alliance with Karen, Nakomis, Adria, Natalie, Lori and Will. While in the house, Diane had a romantic relationship with HouseGuest Drew, which ultimately led to her turning on the girls alliance. Diane often fought with Jase and Scott during their time in the house, and strongly disliked Holly, despite acting like her friend. Despite being a target for the Four Horsemen in the early weeks, her friendship with Drew played a role in keeping her safe. She was the first female Head of Household this season, after winning a nine-hour-long endurance competition. She nominated Jase and Scott for eviction, culminating in Scott's eviction. The following week, Diane was nominated for eviction as part of Nakomis's "Six Finger Plan", which led to Drew winning the Power of Veto and using it to save Diane. When Adria turned on the girls alliance, Drew and Diane began to side with her, causing Diane's friendship with Nakomis and Karen to strain. Diane was nominated for eviction a second time on Day 64, but won her first Power of Veto competition and saved herself. On Day 66, Diane won her second consecutive Power of Veto competition, and later used it to save Drew. She was nominated against Nakomis in the Final Four, but Michael chose to cast the sole vote in Diane's favor. On Day 78, Drew won the Final Head of Household competition, and shockingly cast the sole vote to evict his romantic partner Diane. She came in third place. She was the seventh member of the jury, and voted for Drew to win.

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