In college football, games in which 100 points are scored by a single team are a rarity, especially since 1940; in lopsided games, several deterrents exist to prevent running up the score. Of current NCAA Division I Football Bowl Subdivision (FBS) teams, only Arizona, Bowling Green, Georgia Tech, Oklahoma and Tulsa have eclipsed 150 points in a game. Neglecting games in the early 1900s, the Houston Cougars are the only Division I FBS football team to score 100 points against another FBS team, against Tulsa in 1968. The most lopsided game in college football history occurred in a 1916 contest when Georgia Tech beat Cumberland 222–0.King College (TN), now King University, scored 206 points against Lenoir in 1922 and the former St. Viator College (IL) put up 205 points against Lane in 1916.
On September 25, 1884, Yale defeated Dartmouth 113–0, becoming not only the first game where one team scored over 100 points but also first time one team scored over 100 points and the opposing team scored zero points. The next week, Princeton outscored Lafayette by 140 to 0.
It is rare for a team to have scored in a game when the opponent scored over 100 points, but several cases exist. One is the Rice–Southern Methodist game of 1916 when SMU scored an early field goal but Rice "came back" to win 146–3.