"Let's Twist Again" is a song written by Kal Mann and Dave Appell, and released as a single by Chubby Checker. One of the biggest hit singles of 1961, it reached No.8 on the U.S. Billboard pop chart (No.3 on Cash Box) in August of that year and subsequently reached No.2 in the U.K. in February 1962. The song refers to the Twist dance craze and Checker's 1960 single "The Twist", a two-time U.S. No.1 single (in September 1960 and again in January 1962 on re-release).

The song received the 1962 Grammy Award for Best Rock & Roll Recording. Checker also recorded the song in German as "Der Twist Beginnt" and in Italian as "Balliamo il Twist". The song appears on the soundtrack of the 2011 film The Help.

Croatian singer Tatjana Cameron Tajči made a remake of the song in Croatian renaming it Moj mali je opasan. In 1985 Kids Incorporated covered "Let's Twist Again" in the Season 2 episode "Rock of Ages".

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