Leonor Lasso de la Vega (b. before 1367 - d. 1432) was a Spanish noble woman from Cantabria and head of the prestigious House of Lasso de la Vega from 1367 - 1432.
Leonor was the paternal great-granddaughter of Garci Lasso de la Vega I, the chancellor of the Kingdom of Castile, who was executed in 1326 by order of King Alfonso XI of Castile, and his wife Juana de Castañeda. She was the paternal granddaughter of Garci Lasso de la Vega II, assassinated by Peter of Castile in 1351, who was the highest royal official to the court of Fadrique Alfonso de Castilla, son of King Alfonso XI of Castile, and his wife, Leonor González de Cornado. She was the only daughter of Garci Lasso Ruiz de la Vega, who spent his life in the service of Henry II of Castile and was killed at the Battle of Nájera in 1367 whereupon Leonor rose to the position of head of house.
She was a lifelong benefactor of the Monasterio de Santa Clara de Castrojeríz which was founded by her grandparents, Garci Lasso de la Vega II and Leonor González de Cornado.
Leonor's first marriage was with Juan Téllez de Castilla, the second lord of Aguilar de Campoo and the second lord of Castañeda. He was the son of Tello de Castilla who was in turn, the illegitimate son of Alfonso XI of Castile and Leonor de Guzmán. The couple had the following children: