Leland H. Hartwell
| Leland H. Hartwell | |
|---|---|
| Born |
October 30, 1939 Los Angeles, California, U.S. |
| Residence | American |
| Fields | Biology |
| Institutions |
Fred Hutchinson Cancer Research Center Arizona State University Biodesign Institute Amrita Vishwa Vidyapeetham |
| Alma mater | California Institute of Technology, Massachusetts Institute of Technology |
| Known for | Cell cycle regulation |
| Notable awards | Albert Lasker Award (1998) Genetics Society of America Medal (1994) Massry Prize (2000) Nobel Prize in Physiology or Medicine (2001) Medal of Merit (2003) Komen Brinker Award |
Leland Harrison (Lee) Hartwell (born October 30, 1939, in Los Angeles, California) is former president and director of the Fred Hutchinson Cancer Research Center in Seattle, Washington. He shared the 2001 Nobel Prize in Physiology or Medicine with Paul Nurse and Tim Hunt, for their discoveries of protein molecules that control the division (duplication) of cells.
Working in yeast, Hartwell identified the fundamental role of checkpoints in cell cycle control, and CDC genes such as CDC28, which controls the start of the cycle—the progression through G1.
Hartwell attended Glendale High School in Glendale, California, and then received his Bachelor of Science from the California Institute of Technology in 1961. In 1964, he received his Doctor of Philosophy in biology from the Massachusetts Institute of Technology. From 1965 to 1968, he worked at the University of California, Irvine as a professor. He moved to the University of Washington in 1968. In a series of experiments from 1970 to 1971, Hartwell discovered the cell division cycle (CDC) genes in baker's yeast (Saccharomyces cerevisiae). These genes regulate the cell cycle and mutations in the genes are involved in some types of cancer.
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