Left-hander

Handedness is a better (faster or more precise) performance or individual preference for use of a hand, known as the dominant hand. Handedness is not a discrete variable (right or left), but a continuous one that can be expressed at levels between strong left and strong right.

There are four types of handedness: left-handedness, right-handedness, mixed-handedness, and ambidexterity. Left-handedness is somewhat more common among men than among women.

There are several theories of how handedness develops in individual humans. Occurrences during prenatal development may be important; researchers studied fetuses in utero and determined that handedness in the womb was a very accurate predictor of handedness after birth. In a 2013 study, 39% of infants (6 to 14 months) and 97% of toddlers (18 to 24 months) demonstrated a hand preference.

One common theory, as to how handedness affects the hemispheres, is the brain hemisphere division of labor. Since speaking and handiwork require fine motor skills, its presumption is that it would be more efficient to have one brain hemisphere do both, rather than having it divided up. Since in most people, the left side of the brain controls speaking, right-handedness predominates. This theory also predicts that left-handed people have a reversed brain division of labor.

Verbal processing in right-handed individuals takes place mostly in the left hemisphere, whereas visuospatial processing is mostly done in the opposite hemisphere. Left-handed individuals have a heterogeneous brain organization in which their brain hemisphere is either organized in the same way as right-handers (but with the hemispheres reversed) or even such that both hemispheres are used for verbal processing. When the average is taken across all types of left-handedness, it shows that left-handers are less lateralized.

Handedness displays a complex inheritance pattern. For example, if both parents of a child are left-handed, there is a 26% chance of that child being left-handed. A large study of twins from 25,732 families by Medland et al. (2006) has indicated that the heritability of handedness is roughly 24%.

To date, two theoretical single gene models have been proposed to explain the patterns of inheritance of handedness, the first by Marian Annett of the University of Leicester and the second by Professor Chris McManus of UCL.

However, the growing weight of evidence from linkage and genome-wide association studies suggests that genetic variance in handedness cannot be explained by a single genetic locus. From these studies McManus et al. now conclude that handedness is polygenic and estimate that at least 40 loci contribute to determining this trait.

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