Leatherwood Plantation of 10,000 acres (40 km2) was located in Henry County, Virginia, where Patrick Henry lived from 1779 until 1784. The plantation is probably named after Leatherwood Creek, a tributary to the Smith River (Virginia), which ran through the property.
Patrick Henry purchased Leatherwood and jointly owned it along with his first cousin, Ann Wilson Carr and her husband, George Waller. After Patrick Henry completed his first term as the first elected governor of Virginia in 1776, he moved to a brick home on Leatherwood plantation. There he grew tobacco and practiced law. In 1780, Henry County was named in his honor, and sent him back to the capital as their representative to the Virginia House of Delegates. Several of his children were born there during his residency.
Henry's daughter, Martha, lived and administrered the plantation. "Martha (Patsey) born 1755 at "Pine Slash," died 1818, age 63 at “Leatherwood” in 1818, married 2 Oct 1773 to John Fontaine born 1750 at Beaverdam, VA, died at “Leatherwood” in 1792 of malaria. Martha, widowed at 37, managed Leatherwood plantation, administered the will of her husband and of her brother William; Martha and John buried at Leatherwood, Henry Co., VA." His son, John, also lived there. "John born 1757 at "Pine Slash," died ca. 1791 at age 34 at “Leatherwood,” Revolutionary War soldier, buried in unmarked grave at "Leatherwood," Henry Co., VA, married Susannah Walker (she remarried 1798 to Richard White and died in Abingdon, VA)." His daughters, Sarah (Sallie) Butler, was born at Leatherwood on January 4, 1780, as was her sister, Martha Catharine (Kitty), born November 3, 1781. His son, Patrick Henry, Jr., was also born at Leatherwood on August 15, 1783.
Patrick Henry's son, John, was given 1,000 acres of the Leatherwood plantation to farm on his own, along with seven of the 42 slaves held there, in 1778.
Patrick Henry also saw the Leatherwood plantation as far removed from the combat in eastern Virginia, and thought his family safer from British forces while in Henry County.
Colonel Patrick Henry Fontaine, born of John and Martha Henry Fontaine, was a grandson of Patrick Henry, and was born on the site. The plantation was given to Henry's son-in-law and daughter upon their marriage.
The Leatherwood plantation later passed to the Hairston family. In 1832, Robert Hairston arranged for six slaves to be sent from the plantation to freedom in Liberia. The names of the freed slaves were not recorded.