"Lay Your Hands on Me" is a song by American rock band Bon Jovi. It was released on August 1 1989 as the fourth single from the band's 1988 album New Jersey. It peaked at #7 on the Billboard Hot 100, becoming the band's fourth single from New Jersey to chart in the Top 10 and it also charted at #20 on the Mainstream rock charts.

The song runs 6 minutes, with a long intro focused on the drum beats of Tico Torres and keyboard playing of David Bryan as well as the chants of the crowd: "hey!", before going into an extremely hard rock song, filled with loud guitar riffs by Richie Sambora and the husky delivery of lyrics by Jon Bon Jovi. By Jon's own admission, this is one of the few Bon Jovi songs that was written from a guitar riff (Jon Bon Jovi's usual style is to begin writing a song with the title). It was written in the studio while they were recording the New Jersey album.

The video for this song was culled from performances at the Tacoma Dome in Tacoma, WA and the Memorial Coliseum in Portland, OR during The Jersey Syndicate Tour. It was also released to home video on New Jersey: The Videos and Cross Road: The Videos. The MTV video for "Lay Your Hands On Me" was shot in Salt Lake in May 1989.

For live performances through the 80s and 90s, Sambora would use a double neck guitar with one neck tuned to drop D and the other tuned to Standard tuning. Examples of this can be seen in the official video clip, as well as in the Live From London DVD. During the 2000s he began using a single-necked guitar, as can be seen in The Crush Tour DVD. The song was performed a few times on the Lost Highway Tour. During recent performances on The Circle Tour, the song has been performed with Sambora on lead vocals.

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