The cabinet of Danish Prime Minister Lars Løkke Rasmussen, was announced on 5 April 2009 as Lars Løkke became prime minister after Anders Fogh Rasmussen was offered the post of Secretary General of NATO on 4 April 2009.
Following the 2011 parliamentary election, Lars Løkke Rasmussen was replaced as Prime Minister of Denmark by the Social Democrat Helle Thorning-Schmidt.
On 7 April 2009 Lars Løkke Rasmussen announced the following changes from the cabinet of Anders Fogh Rasmussen III:Claus Hjort Frederiksen became Minister of Finance after Lars Løkke Rasmussen, and Frederiksen's previous post of Minister of Employment is filled by Inger Støjberg, previously not a minister, who also becomes Minister for Equal Rights. Following Karen Jespersen's announcement that she wished to withdraw as Minister for Social Welfare, that ministry is abolished and a new combined ministry of the interior and of social affairs is taken over by Karen Ellemann.
On 23 February 2010 Løkke Rasmussen announced a major reshuffle, which affected all ministers except for Claus Hjort Frederiksen, Birthe Rønn Hornbech and the prime minister himself.
On 8 March 2011 some minor changes were announced in connection with the firing of Birthe Rønn Hornbech from her position as Minister for Integration as a result of a scandal involving the right of citizenship for stateless residents.