The Lamine River (/ləˈmiːn/ lə-MEEN) is a 63.8-mile-long (102.7 km)tributary of the Missouri River in central Missouri in the United States. It is formed in northern Morgan County, Missouri, about 4 miles (6 km) southeast of Otterville by the confluence of Flat Creek and Richland Creek, and flows generally northwardly through Cooper and Pettis counties. In northwestern Cooper County the Lamine collects the Blackwater River and flows into the Missouri River, 6 miles (10 km) west of Boonville.
The river was named by French explorers for mining operations in the area. According to the Geographic Names Information System, the river has also been known as "La Mine River" and as "Riviere a la Mine."