The Lafayette–Opelousas–Morgan City combined statistical area is made up of six parishes in the Acadiana region of southern Louisiana. The statistical area consists of the Lafayette Metropolitan Statistical Area (MSA) and two micropolitical statistical areas (μSAs) – Opelousas, Louisiana Micropolitical Statistical Area and Morgan City, Louisiana Micropolitical Statistical Area. As of the 2010 census, the CSA had a population of 604,784 (though a 2015 estimate placed the population at 627,146).
The CSA is home to a large Cajun population and is also known as the "Cajun heartland".
As of the census of 2010, there were 550,134 people, 188,219 households, and 134,322 families residing within the CSA. The racial makeup of the CSA was 70.42% White, 27.07% African American, 0.25% Native American, 1.01% Asian, 0.02% Pacific Islander, 0.40% from other races, and 0.84% from two or more races. Hispanic or Latino of any race were 1.35% of the population. Of the total population over the age of 5, 83.4% (419,800) spoke English and 12.7% (64,001) spoke French (including Cajun French and Louisiana Creole French).