Lactucarium

Lactucarium
Product name	Lactucarium
Source plant(s)	Lactuca spp.
Part(s) of plant	latex (see also seeds)
Geographic origin	Southern Europe
Uses	analgesic, sleep aid, euphoriant

Lactucarium is the milky fluid secreted by several species of lettuce, especially Lactuca virosa, usually from the base of the stems. It is known as lettuce opium because of its putative sedative and analgesic properties. It has also been reported to promote a mild sensation of euphoria, and at least one fatality has occurred during an attempt to use it for intoxication. Because it is a latex, lactucarium physically resembles opium, in that it is excreted as a white fluid and can be reduced to a thick smokable solid.

"Lettuce opium" was used by the ancient Egyptians, and was introduced as a drug in the United States as early as 1799. The drug was prescribed and studied extensively in Poland during the nineteenth century, and was viewed as an alternative to opium, weaker but lacking side-effects, and in some cases preferable. However, early efforts to isolate an active alkaloid were unsuccessful. It is described and standardized in the 1898 United States Pharmacopoeia and 1911 British Pharmaceutical Codex for use in lozenges, tinctures, and syrups as a sedative for irritable cough or as a mild hypnotic (sleeping aid) for insomnia. The standard definition of lactucarium in these codices required its production from Lactuca virosa, but it was recognized that smaller quantities of lactucarium could be produced in a similar way from Lactuca sativa and Lactuca canadensis var. elongata, and even that lettuce-opium obtained from Lactuca serriola or Lactuca quercina was of superior quality.

...
Wikipedia