The 2010–11 Greek Cup was the 69th season of the Greek Football Cup. A total of 67 clubs had been accepted to enter, after the withdrawal of Egaleo, Kalamata and Pyrsos Grevena and their relegation to Delta Ethniki.

The competition commenced on 4 September 2010 with the First Round and concluded on 30 April 2011 with the Final, held at Athens Olympic Stadium "Spyridon Louis". The final was contested by Atromitos and AEK Athens, that won 3-0 in the final.

The following 67 teams competed in First Round:

The draw for this round took place on 18 August 2010.

Anagennisi Giannitsa, Eordaikos 2007 and Chersonissos qualified without matches to Second Round.

All times UTC+3

The draw for this round took place on 18 August 2010.

All times UTC+3

The draw for this round took place on 18 August 2010.

All times UTC+3

The draw for this round took place on 18 August 2010.

All times (excl. Ilioupoli vs. Olympiacos) UTC+3