Kyōgoku Takatsugu (京極 高次?, 1560 – June 4, 1609) was a daimyō (feudal lord) of Ōmi Province and Wakasa Province during the late Sengoku period of Japan's history.
Takatsugu is recognized as the founder of the modern Kyōgoku clan. His forebears had been powerful since the 13th century, but their fortunes had waned after the Ōnin War. Takatsugu is credited with restoring his family's lost prominence and position.
Takatsugu allied himself with Oda Nobunaga; and after Nobunaga's death, Takatsugu became a fudai (hereditary vassal) daimyo of the Toyotomi. Hideyoshi installed Takatsugu at Ōtsu Castle (60,000 koku) in Ōmi province.
In 1600, he sided with the Tokugawa. On the same day as the Battle of Sekigahara, failed in his efforts at the Siege of Ōtsu, but Tokugawa Ieyasu's victory at Sekigahara marginalized the consequences of that loss. In that same year, Takatsugu was rewarded with the fief of Obama (92,000 koku) in Wakasa Province.
Under the Tokugawa shogunate, the Kyōgoku were identified as tozama or outsiders, in contrast with the fudai daimyo who were hereditary vassals of the Tokugawa. Despite this, Takatsugu prospered.
The tozama Kyōgoku claimed descent from Emperor Uda (868–897) by his grandson Minamoto no Masanobu (920–993). They represent a branch of the Sasaki clan who were adopted by the Seiwa Genji.