Kyōgoku Takayoshi (京極高吉?, 1508 – 28 February 1581) was a son of Kyōgoku Takahide and a nominal vassal of the Asai clan. Following Ashikaga Yoshiteru's murder in 1565, Takayoshi attended to Ashikaga Yoshiaki. He fell out of favour with Oda Nobunaga after Ashikaga Yoshiaki's banishment from Kyoto in 1573.