The Kurilpa state by-election, 1949 was a by-election held on 10 September 1949 for the Queensland Legislative Assembly seat of Kurilpa, based in the inner southern Brisbane suburbs of West End and South Brisbane.
The by-election was triggered by the death of Labor member Patrick Copley on 18 July 1949. The seat was a swinging seat between Labor and non-Labor, although Copley had held it since the 1932 election and it was expected to be retained by the party.
The by-election attracted three candidates. The Labor Party nominated Thomas Moores, the incumbent alderman for the Kurilpa Ward on Brisbane City Council whose boundaries were identical to the Assembly seat. The Liberal Party nominated Norman Brandon, while the Communist Party nominated Anna Slater. It was the first electoral contest held since the Queensland People's Party became the Liberal Party's Queensland branch, along with the Ipswich state by-election held on the same day.
Thomas Moores retained the seat for the Labor Party.
Upon Moores' election, the Kurilpa Ward council seat was filled at a by-election on 12 November 1949 by Colin Bennett, who went on to be the leader of Municipal Labor on Brisbane City Council during the 1950s, and subsequently held the Legislative Assembly seat of South Brisbane from 1960 until 1972.