Krobo Edusei (26 December 1914 – 13 February 1984) was a Ghanaian politician and a high-profile member of Kwame Nkrumah's government. He was a popular, outspoken and prominent Ashanti activist and at the forefront of the Ghanaian independence movement, galvanising support amongst the Ashantis for Nkrumah's independence movement. He served as Minister without Portfolio, Minister for Agriculture, Minister for Transport and Communication and Minister for the Interior under Nkrumah.
Following the overthrow of Nkrumah's government, Edusei was imprisoned and subsequently released. He continued to be politically active and very influential as a senior member of the People's National Party (PNP), a party formed from the ashes of Nkrumaist CPP; and when the PNP went on to win Ghana's second (the first was won by Dr Kofi Abrefa Busia) post-Nkrumah elections, Edusei became a powerful figure in Hilla Limann's government. Following the 1981 overthrow of the Limann government, Edusei was again imprisoned, He was released in 1983 and died of complications from diabetes soon after.
Krobo Edusei married three times and had numerous children who remain active in the Ghanaian business world. The more well known of his children include prominent millionaire Ghanaian businessman and ports operator, Yaw Krobo Edusei, Lucy Lamptey, former legal director of the Ghanaian government agency Social Security and National Insurance Trust (SSNIT), Comfort Emden, a real estate entrepreneur and conservationist and Catherine Krobo Edusei, entrepreneur, owner and CEO of the Eden Tree brand.