The Kražiai College was a Jesuit college (equivalent to a modern secondary school) in Kražiai, Grand Duchy of Lithuania and later Russian Empire. Established in 1616 in hopes to educate new generations of anti-Protestants, the college was one of the major cultural and educational centers in Samogitia. In 1620–1742, it shared premises with the Samogitian Priest Seminary. In 1844, the college was transferred to Kaunas.
Bishop Merkelis Giedraitis raised the idea of establishing a college in Kražiai, the first higher education institution in Samogitia. To that end, in 1608, he invited the Jesuits, bought them land and built a house for their needs. Merkelis died the following year; in his last will, he left money and land for the construction of a Jesuit monastery. Other patrons included Mikołaj Krzysztof "the Orphan" Radziwiłł who donated a palace, built in 1565, and Jan Karol Chodkiewicz who donated seven homesteads. The college was founded in 1613, and was called Collegium Chodkievicianum in honor of Chodkiewicz. The first class was held only in September 1616 in a temporary wooden house. The construction of a permanent school began in 1618 (the ceremony of laying the cornerstone was attended by Grand Treasurer Hieronim Wołłowicz). At the time, the college already had about 50 students and 12 teachers.
Gradually, with the support of many wealthy sponsors, the college expanded into a large campus, including its own church built in 1625–89. Full financial support was given to 26 impoverished students. On average, the school employed 30–50 Jesuits and educated 250–300 students. The curriculum and teaching methods followed the Ratio Studiorum. Students belonged to the Sodality of Our Lady and visited the sick. The college had its own student theater (30 performances are known) and a rich library, which in 1803 held 3,264 volumes (oldest dating back to 1427).