Koca Mustafa Pasha (died 1512) was an Ottoman statesman. He was grand vizier of the Ottoman Empire from 1511 to 1512. He was Greek (Rum) and not a devşirme.
He started his career as kapıcıbaşı, that is "chief doorkeeper" of the Topkapi Palace: in this office he acted also as Master of Ceremonies at receptions of foreign ambassadors. Appointed Grand Vizier near the end of the reign of Bayezid II, he was executed in 1512. In Istanbul he let convert into mosques two ancient Byzantine churches, which were both named after him respectively Koca Mustafa Pasha and Atik Mustafa Pasha Mosque.