The Keystone Corridor is a 349-mile (562 km) railroad corridor between Philadelphia and Pittsburgh, Pennsylvania that consists of two rail lines, the Amtrak Philadelphia to Harrisburg Main Line (which includes the Southeastern Pennsylvania Transportation Authority (SEPTA) Paoli/Thorndale Line commuter rail service) and the Norfolk Southern Pittsburgh Line. The corridor was originally a rail line itself as it was the Main Line of the Pennsylvania Railroad.
The rail corridor is one of the high-speed corridors designated by the Federal Railroad Administration (FRA). Since 2006, the track from Lancaster to Parkesburg has permitted trains of up to 110 miles per hour (180 km/h), while the section between Paoli and Philadelphia allows 75 to 90 miles per hour (121 to 145 km/h).
Amtrak runs two intercity rail services along the Keystone Corridor: the Harrisburg-to-New York City Keystone Service and the Pittsburgh-to-New York City Pennsylvanian. The Southeastern Pennsylvania Transportation Authority (SEPTA) operates daily Paoli/Thorndale commuter rail service between Philadelphia and Thorndale on the Philadelphia to Harrisburg Main Line, serving the communities along the eastern part of line, the Philadelphia to Thorndale part of the line is a socio-cultural region called the "Philadelphia Main Line".