Jules Jean Baptiste Vincent Bordet
| Jules Bordet | |
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Jules Bordet
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| Born |
Jules Jean Baptiste Vincent Bordet 13 June 1870 |
| Died | 6 April 1961 (aged 90) |
| Resting place | Ixelles Cemetery |
| Alma mater | Free University of Brussels |
| Awards | |
Jules Jean Baptiste Vincent Bordet (13 June 1870 – 6 April 1961) was a Belgian immunologist and microbiologist. The bacterial genus Bordetella is named after him.
Bordet was born at Soignies, Belgium. He graduated as Doctor of Medicine from the Free University of Brussels in 1892 and began his work at the Pasteur Institute in Paris in 1894, in the laboratory of Elie Metchnikoff, who had just discovered phagocytosis of bacteria by white blood cells, an expression of cellular immunity.
In 1895 Bordet made his discovery that the bacteriolytic effect of acquired specific antibody is significantly enhanced in vivo by the presence of innate serum components which he termed alexine (but which are now known as complement). Four years later, in 1899, he described a similar destructive process involving complement, "hemolysis", in which foreign red blood cells are ruptured or "lysed" following exposure to immune serum. In 1900, he left Paris to found the Pasteur Institute in Brussels but continued to work extensively on the mechanisms involved in the action of complement. These studies became the basis for complement-fixation testing methods that enabled the development of serological tests for syphilis (specifically, the development of the Wassermann test by August von Wassermann). The same technique is used today in serologic testing for countless other diseases.
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