Juan Bautista de Toledo (c. 1515 - 19 May 1567) was a Spanish architect. He was educated in Italy, in the Italian High Renaissance. As many Italian renaissance architects, he had experience in both architecture and military and civil public works. Born, either in Toledo or in Madrid around 1515. He died on 19 May 1567 in Madrid, and was buried in Madrid in the choir of the primitive “Convento de Santo Tomás, Iglesia de la Santa Cruz”.
Perhaps he started his career in architecture in Rome, between 1534 and 1541, working for Michelangelo and Pope Paul III (Alessandro Farnese), completing the facade and courtyard of Palazzo Farnese. Then, possibly, he continues his training in the construction site of St. Peter's, under the direction of Antonio da Sangallo the Younger. Another hypothesis is that he worked for Antonio da Sangallo the Younger in both Fortaleza da Basso, Florence and St. Peter’s Basilica of Rome.
Juan Bautista de Toledo, an enigmatic and puzzling personality, was known in Florence and Rome as Giovanni Battista de Alfonsis. However, in Naples and Madrid, he was identified as Juan Bautista de Toledo: both Spanish architects had the same hand writing. Perhaps, his true name was Juan Bautista de Toledo Alfonsis.
In El Escorial, his most significant job, on 23 April 1563, in the ceremony of the masonry stone (cornerstone), Juan de Herrera wrote over the visible side of the first stone, "JOANNES BAPTISTA ARCHITECTUS MAJOR. APRILES 23". In the other sides of the first stone, the inscriptions are: in one side, "DEUS OPTIMUS MAXIMUS OPERO ASPICIAT"; and in the other side, "PHILIPUS HISPANIARUM REX A FUNDAMENTIS ERIXIR −1563": "En 23 dias del mes de abril, dia de San Jorge mártir, deste año de 1563 se puso la primera piedra del monasterio en el cimiento del reflectorio, debajo de la silla del prior, que es en la bodega, debajo del dicho reflectorio, la cual piedra es cuadrada y está escrita por todas partes, que da a entender quien es el fundador, y quien es el arquitecto y el día y año en que se pone".