José de Antequera y Castro (Panama, 1689—Peru, July 5, 1731) was a Panamanian lawyer and judge in the Viceroyalty of Peru (then including Panama, Bolivia and Paraguay), and the leader of an insurrection in Paraguay against the viceroy and the king.
Antequera y Castro was born in Panama. He was an oidor (judge) in the Audiencia of Panama before traveling to Spain. He became a knight of the Order of Alcántara. He was public prosecutor before the Audiencia of Charcas (Alto Peru, now Bolivia) in charge of protecting the Indians.
He was sent from Charcas to Asunción, Paraguay in 1721 as an inspector and member of the Audiencia there. His instructions were to investigate charges made by the cabildo (city council) of Asunción against the governor of Paraguay, Diego de los Reyes Balmaseda. If the governor's guilt was established, Antequera was to remove him from office, occupy the office himself, and reestablish justice in the province. If, on the other hand, the governor was acquitted, Antequera was to wait until the expiration of his legal term in office, and then take over the government.
Reyes Balmaceda was removed as governor, and Antequera earned the sympathy of the Spanish settlers in Paraguay. After the removal of Reyes, the Criollos named Antequera to take his place. Antequera became acting governor in August 1721. Reyes Balmaceda was restored in February 1722, but before the year was out, Antequera was again governor. He retained the position until March 5, 1725.
The Jesuits, however, were supporters of the dismissed governor. They had been working actively to shelter the Indians from the forced-labor demands of the colonists, and were therefore resented by the colonists. Reyes Balmaceda had supported the Jesuits, and it was that connection that led to the colonists' call for his removal. After Antequera consolidated his power, he expelled the Jesuits.
He then defeated a royalist force from Buenos Aires under García Ros. Reyes Balmaceda had fled to Corrientes, and in a surprise raid there, Antequera took him prisoner. There were suspicions he intended to proclaim himself king, independent of Spain.