John Vane
| Sir John Vane | |
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| Born | John Robert Vane 29 March 1927 Tardebigge, Worcestershire |
| Died | 19 November 2004 (aged 77) Kent |
| Citizenship | British |
| Nationality | English |
| Fields | Pharmacology |
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| Alma mater |
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| Thesis | Blood flow and its relation to secretion in the stomach and smaller intestine (1952) |
| Doctoral advisor | Geoffrey S. Dawes |
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| Spouse | Elizabeth Daphne Page (m. 1948) |
Sir John Robert Vane FRS (29 March 1927 – 19 November 2004) was an English pharmacologist who was instrumental in the understanding of how aspirin produces pain-relief and anti-inflammatory effects and his work led to new treatments for heart and blood vessel disease and introduction of ACE inhibitors. He was awarded the Nobel Prize in Physiology or Medicine in 1982 along with Sune Bergström and Bengt Samuelsson for "their discoveries concerning prostaglandins and related biologically active substances".
Born in Tardebigge, Worcestershire, John Vane was one of three children and grew up in suburban Birmingham. His father, Maurice Vane, was the son of Jewish Russian immigrants and his mother, Frances Vane, came from a Worcestershire farming family. He attended a local state school from age 5, before moving on to King Edward's School in Edgbaston, Birmingham. An early interest in chemistry was to prove the inspiration for studying the subject at the University of Birmingham in 1944.
During his undergraduate studies, Vane became disenchanted with chemistry but still enjoyed experimentation. When Maurice Stacey, the Professor of Chemistry at Birmingham, was asked by Harold Burn to recommend a student to go to Oxford and study pharmacology, Vane jumped at the chance and moved to Burn's department in 1946. Under Burn's guidance, Vane found motivation and enthusiasm for pharmacology, writing: "[the] laboratory gradually became the most active and important centre for pharmacological research in the U.K. and the main school for training of young pharmacologists." Vane completed a Bachelor of Science degree in pharmacology and briefly went to work at the University of Sheffield, before coming back to Oxford to complete his Doctor of Philosophy degree in 1953 supervised by Geoffrey Dawes.
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