John Holles, 1st Duke of Newcastle-upon-Tyne , KG, PC (9 January 1662 – 15 July 1711) was an English peer.
He was born in Edwinstowe, Nottinghamshire, the son of the 3rd Earl of Clare and his wife Grace Pierrepont. Grace was daughter of The Hon. William Pierrepont and granddaughter of the 1st Earl of Kingston-upon-Hull.
Holles was elected MP for Nottinghamshire as Lord Houghton on 14 January 1689, but was called to the House of Lords two days later when his father died and he became the 4th Earl of Clare. He was created the 1st Duke of Newcastle-upon-Tyne, of the 2nd creation, in 1694. The Duke of Newcastle-upon-Tyne is a title which was created three times in British history. The first creation had become extinct when Henry Cavendish, 2nd Duke of Newcastle-upon-Tyne died with out a male heir.
On 1 March 1690, he married Lady Margaret Cavendish, a daughter of Henry Cavendish. They had one child, Lady Henrietta Cavendish Holles (1694–1755), who married the 2nd Earl of Oxford and Mortimer and was mother to Margaret Bentinck, Duchess of Portland.
In 1710 he purchased Wimpole Park in Cambridgeshire and the Manor of Marylebone. The Marylebone lands passed to his son-in-law Harley who named Holles Street in his memory.