John Hampden (c. 1696 – 4 February 1754), an English politician, was the second son of John Hampden.
He was a founding governor of London's Foundling Hospital, a charity dedicated to the salvation of the capital's abandoned children.
He married Isabella Ellys, but left no children. He was the last male-line descendant of John Hampden, and left his estates on his death to his cousin Hon. Robert Trevor, who assumed the Hampden surname.