Jefferson Boulevard is a street in Los Angeles and Culver City. Its eastern terminus is at Central Avenue east of Exposition Park. At its entrance to Culver City, it splits with National Boulevard. North of Sawtelle Boulevard, it merges with Sepulveda Boulevard. Jefferson returns before Slauson Avenue and ends at Culver Boulevard; its western terminus is near Playa Del Rey.
University of Southern California (USC) is located on Jefferson Boulevard from Figueroa Street to Vermont Avenue. Its sports arena, the Galen Center, is located at the southeast corner of Jefferson and Figueroa.
Bus service is operated through Jefferson Boulevard between Playa Vista and Culver City by Metro Local line 110, Culver City and West L.A. Transit Center by Culver City Transit line 4, West LA Transit Center and USC by Metro Local line 38, and east of USC by Metro Local line 102. The Metro Expo Line serves two stations at Jefferson: one at Flower Street near USC and the other on La Cienega Boulevard.
Los Angeles saw an influx of Louisiana Creole people to the area in the mid-1900s, to the point that by the 1950s a portion of Jefferson Boulevard and Jefferson Park (a neighborhood that ran partially along Jefferson Boulevard) was unofficially dubbed "Little New Orleans". The population was predominantly Creole and held many Creole-owned businesses such as the Big Loaf Bakery, which was considered to be the "only place in Los Angeles that made New Orleans style French bread".