Protein Wisdom is a constitutional conservative-libertarian weblog created by former academic and sometime fiction writer Jeff Goldstein—a self-described classical liberal.
Barrett Brown of The Huffington Post has described the blog as catering to "one of the most collectively cerebral audiences one may find within the right side of the blogosphere". Goldstein's respect for the legacy of Hunter S. Thompson is an enduring theme, as is his sardonic allusions to such popular cult figures as Martha Stewart and the fictional Billy Jack. The blog is known for its bawdy overtones, surrealistic sense of humor, and biting wit. The site moved past the nine-million-hit mark in March 2008; Goldstein is noted for his eccentric, intellectual work, best captured in his oddball collections of posts (e.g., "red pills found behind the sofa cushions," and "the protein wisdom conceptual series"). He's also known for his highly ironic entries (one of which was picked up by Howard Kurtz of The Washington Post), and discussions of hermeneutics (from an intentionalist stance), with a concentration on how interpretive strategies both inform and reinforce certain philosophical assumptions and, by extension, social policies. Goldstein is particularly critical of identity politics,racialism and multiculturalism. The blog's title comes from a line in a piece of Goldstein's fiction, written during his years at the University of Denver, and relates to the idea of the possibility of genetic memory; any connection to other iterations of the phrase are coincidental.
Goldstein vocally opposed the abrupt change of financial arrangements by Pajamas Media in 2009, which deprived him — and other bloggers such as The Anchoress and Ace of Spades HQ — of income from PJM-mediated advertising. He also publicly chastised those he refers to as GOP pragmatists or realists for their criticism of Rush Limbaugh's answer to a question about the coming Obama presidency, once again relying on linguistics and hermeneutics to make the point that "losing more slowly" is still losing, and that there is nothing more pragmatic, as a political strategy, than standing on principle