Jean de Monluc (died 1579) was a French noble, clergyman, diplomat, and courtier. He was the second son of François de Lasseran de Massencome, a member of the Monluc family; and Françoise d' Estillac. His birthplace is unknown, but it has been observed that his parents spent a great deal of time at their favorite residence at Saint-Gemme in the commune of Saint-Puy near Condom. Jean's elder brother Blaise de Lasseran-Massencôme, seigneur de Montluc became a soldier, and eventually Marshal of France (1574).
Jean began his religious career as a young Dominican novice, in either their Convent in Condom or the one in Agen. From the beginning he showed outstanding talent as a public speaker. He was introduced to Queen Marguerite de Navarre, the sister of King Francis I of France, who often stayed in her chateau at Nérac, just north of Condom, and quickly became part of her entourage, abandoning his life as a Dominican monk.
In 1524 Jean de Monluc served as an attaché to the French Embassy in Rome. In 1536, now a Protonotary Apostolic, he was again assigned to the Embassy being sent to Rome headed by Bishop Charles Hémard of Mâcon. In 1537 Monluc was sent with a personal viva voce message from King Francis I to Pasha Khizir Khayr ad-Dîn (Barberousse), the Captain General of the Ottoman fleet, who was beginning a campaign against the coasts of Italy. In July 1537, the Pasha landed at Otranto and captured the city, as well as the Fortress of Castro and the city of Ugento in Apulia. Monluc set off on 6 August, and a meeting took place with the Pasha on 1 September. On his return journey Monluc was received by Pope Paul III in a public audience, where embarrassing questions were raised about the rumored poisoning of the Dauphin. Details of his embassy were submitted in a letter to Cardinal du Bellay in Paris. He remained in Rome, attached to the French Embassy, under the Comte de Grignan and then Bishop Jean de Langeac of Limoges, at least until 1540.
In ca. 1542 Monluc was sent on a mission to Venice. His assignment was to explain to the Venetians why it had been a good idea for Francis I to ally himself with the Ottoman Turks. It was a thankless task, and a hopeless mission, but one which used Monluc's great gifts of oratory in the service of the King.