Jean-François Ntoutoume Emane (born 6 October 1939) is a Gabonese politician who was Prime Minister of Gabon from 23 January 1999 to 20 January 2006. He was Mayor of Libreville, the capital, from 2008 to 2014.
Ntoutoume Emane is a member of the Fang ethnic group from Estuaire Province. After working at the Ministry of Finance, Ntoutoume Emane was Personal Adviser to President Omar Bongo from 1976 to 1990. On 13 July 1977, he was appointed as Minister and Personal Adviser to the President, responsible for the coordination of the economic and financial affairs of the Presidency as well as civil and commercial aviation. He served as Minister of Civil and Commercial Aviation until 1984, then as Minister of Commerce and Consumer Affairs from 1984 to 1987. In 1990, he was elected to the National Assembly as a candidate of the Gabonese Democratic Party (PDG), defeating opposition leader Paul M'ba Abessole in Lalala. He was appointed to the government of Prime Minister Casimir Oyé-Mba on 25 March 1994 as Minister of State Control, Decentralization, Territorial Administration and Regional Integration, but he declined the position.
Ntoutoume Emane led negotiations with the opposition in 1994 that resulted in the Paris Accords. Standing as a PDG candidate in the fifth arrondissement of Libreville, he again defeated Mba Abessole in the December 1996 parliamentary election. He was appointed as Minister of State for the Land-Survey Register, Housing, Lodgings, Urban Affairs, and Spatial Planning in the government of Prime Minister Paulin Obame-Nguema on 28 January 1997. Although he had been passed over for the post of Prime Minister earlier in the 1990s, Ntoutoume Emane was appointed as Prime Minister in January 1999, after serving as the campaign manager for President Omar Bongo during his successful re-election campaign for the December 1998 presidential election. He won a seat from Libreville as a PDG candidate in the December 2001 parliamentary election. After seven years as Prime Minister, Ntoutoume Emane was replaced by Jean Eyeghe Ndong after Bongo was sworn in for another term in January 2006.