James Tyrrell (May 5, 1642 – June 17, 1718) was an English author, Whig political philosopher, and historian.
James Tyrrell was born in London, the eldest son of Sir Timothy Tyrrell and Elizabeth Tyrrell (née Ussher), the only daughter of Archbishop James Ussher. His younger sister Eleanor married the deist Charles Blount. He lived in Oakley, Buckinghamshire. He was married to Mary Hutchinson (1645-1687), daughter of Sir Michael Hutchinson of Flatbury, Worcestershire. They had at least three children, including James Tyrrell and Mary and another son.
Educated at The Queens College, Oxford (MA, 1663), he became a barrister in 1666 and a justice of the peace in Buckinghamshire. He was deprived of this office by James II for failing to support the Declaration of Indulgence. At the time of the Peace of Rijswijk (1697), he was persuaded back into public service by Thomas Herbert, 8th Earl of Pembroke (Lord Pembroke) to become Commissioner of the Privy Seal.
Tyrrell was a friend and supporter of John Locke, who stayed for a time at Tyrrell's home, at a time when he was apparently working on his Two Treatises on Government. His thinking appears to have been influential in the development of Locke's thinking, and for a time his writings were more influential than Locke's in the emergence of Whig thinking and policies.