James Jackson (3 October 1777 in Newburyport, Massachusetts – 27 August 1867 in Boston) was an American physician. He was a proponent of Massachusetts General Hospital and became its first physician.
He was the son of Newburyport merchant Jonathan Jackson who had been a representative of Massachusetts in the Continental Congress. He graduated from Harvard in 1796, and, after teaching for a year in Leicester Academy, was employed until December 1797 as a clerk for his father, who was then an officer of the government. After studying medicine in Salem for two years, he sailed for London, where he became a “dresser” in St. Thomas's Hospital, and attended lectures there and at Guy's Hospital.
He returned to Boston in 1800, and began a medical practice, which he continued until 1866. In 1803 he became a member of the Massachusetts Medical Society, and in 1810 he proposed with John Collins Warren the establishment of a hospital and an asylum for the insane. Somerville Asylum was soon founded, and afterward the Massachusetts General Hospital was begun in Boston, of which he was the first physician until he resigned in 1835. In 1810 he was chosen professor of clinical medicine at Harvard Medical School, and in 1812 professor of theory and practice, which post he held until 1835, and was afterward professor emeritus until his death. Jackson was elected a Fellow of the American Academy of Arts and Sciences in 1808.