James F. Holland
| James F. Holland | |
|---|---|
| Born |
May 25, 1925 Morristown, New Jersey |
| Education | Columbia University College of Physicians and Surgeons |
| Medical career | |
| Profession | Physician |
| Institutions | National Cancer Institute, Roswell Park Cancer Institute, Icahn School of Medicine at Mount Sinai |
| Specialism | Oncology |
| Research | Combination chemotherapy |
| Notable prizes | Lasker Award, 1972 |
James Frederick Holland (born May 25, 1925) is an American physician and Distinguished Professor of Neoplastic Diseases at the Icahn School of Medicine at Mount Sinai in New York. He is a past president of the American Society of Clinical Oncology and the American Association for Cancer Research. His 1953 clinical trial on acute leukemia resulted in the formation of Acute Leukemia Group B, a research collaboration that later became known as the Cancer and Leukemia Group B. He is considered a key figure in the development of cancer chemotherapy.
Holland was born in Morristown, New Jersey. He completed medical school at the Columbia University College of Physicians and Surgeons and then served as a U.S. Army Medical Corps captain during the Korean War. Holland had secured a hospital job at Presbyterian Hospital in New York before the end of the war, but his tour of duty was extended and Presbyterian Hospital was unable to hold a position for him. Instead, he ended up at Francis Delafield Hospital, which had just opened as a cancer center. Though Holland was initially hoping that another slot would open up at Presbyterian, he found that he preferred to remain at a specialty cancer institution.
In 1953, while Holland was a researcher at the National Cancer Institute (NCI), he designed a clinical trial for the treatment of acute leukemia. The study examined the combined use of two chemotherapy drugs, methotrexate and mercaptopurine. The trial was still in progress the next year when Holland moved to the Roswell Park Cancer Institute (RPCI). When the NCI's new chief of oncology, Gordon Zubrod, agreed to continue the trial, it became the first multicenter study of acute leukemia. Holland conducted further leukemia research with physicians from the NCI and the Children's Hospital of Buffalo. That research group received government funding for the study of chemotherapy. It became known as Acute Leukemia Group B (and later Cancer and Leukemia Group B).
...
Wikipedia