James Cuffe, 1st Baron Tyrawley (1747 – 15 June 1821) was an Irish peer and politician. His father was James Cuff of Elmhall and Ballinrobe Castle and his mother was Elizabeth, sister of Arthur Gore, 1st Earl of Arran.
From 1768 until 1797 Cuffe represented Mayo in the Irish House of Commons. In 1776, he stood also for Donegal Borough and in 1783 for Tuam, however chose both times not to sit. He was created Baron Tyrawley on 7 November 1797 and was elected as one of the first representative peers for Ireland in 1800.
Lord Tyrawley's first wife, Mary Levinge, died without issue in 1808
A tombstone was placed in Ballinrobe churchyard to Henry Cuff, who died 25 August 1811, son of James Cuff, Baron of Tyrawly.
A further tombstone in the same churchyard gives Right Honr. Sarah, Baroness Tyrawly who died 4th October 1820.
Cuffe had an illegitimate son James Cuffe with a London actress. This son was M.P. for Tralee.
James Cuffe's own tombstone reads: To the memory of The Right Honr. James Cuff | Lord Baron Tyrawly | One of his Majestys | Most Honr. Privy Counsil | Late Barrackmaster Genl. | of | Ireland | who died on the 15th June 1821 | Aged ___ years.. Having no legitimate sons living at the time of his death, his title became extinct.