Izzie Stevens

Dr. Izzie Stevens
Grey's Anatomy character
The Season 6 Promotional Photo of Katherine Heigl as Dr. Izzie Stevens
First appearance	"A Hard Day's Night" 1x01, March 27, 2005
Last appearance	"I Like You So Much Better When You're Naked" 6x12, January 21, 2010
Created by	Shonda Rhimes
Portrayed by	Katherine Heigl
Information
Full name	Isobel Katherine Stevens
Nickname(s)	Dr. Model Cricket Izz Izzie Barbie Tinkerbell Stevens Patient X Bethany Whisper Blondie Cancer Wife
Title	M.D.
Family	Robbie Stevens (Mother) Hannah (Daughter)
Spouse(s)	Alex Karev (divorced)
Significant other(s)	Denny Duquette (fiancé, deceased) George O'Malley (deceased)
Religion	Catholicism

Isobel Katherine "Izzie" Stevens, M.D. is a fictional character from the medical drama television series Grey's Anatomy, which airs on the American Broadcasting Company (ABC) in the United States. The character was created by series producer Shonda Rhimes, and was portrayed by actress Katherine Heigl from 2005 to 2010. Introduced as a surgical intern at the fictional Seattle Grace Hospital, Izzie worked her way up to resident level, while her relationships with her colleagues Meredith Grey (Ellen Pompeo), Cristina Yang (Sandra Oh), George O'Malley (T.R. Knight) and Alex Karev (Justin Chambers) formed a focal point of the series.

Heigl was critical of the character's development during the show's fourth season, particularly her romance with George. She declined to put herself forward for the 2008 Emmy Awards, citing insufficient material in the role. After speculation that Izzie would be killed off in the fifth season, the character was diagnosed with Stage 4 metastatic melanoma. She married Alex in the series' one-hundredth episode, and afterwards, her tumor was successfully removed. Izzie made her final appearance in the sixth season, leaving Seattle after Alex ended their relationship. Heigl requested to be released from her contract 18 months early, in order to spend more time with her family. In January 2012, Heigl reported that she would like to return to Grey's Anatomy to give closure to her character, however, Rhimes confirmed that there were no plans to have the character return at that time and has since stated that she has no plans to ever reapproach Izzie's storyline again.