"It's On Again" is a song by American recording artist Alicia Keys, featuring American rapper Kendrick Lamar. The song was written for the 2014 film The Amazing Spider-Man 2 by Keys and Lamar in collaboration with Hans Zimmer, who scored the film, and producer Pharrell Williams, "It's On Again" was released on March 31, 2014 as the lead single from the Amazing Spider-Man 2 soundtrack.

The music video of "It's On Again" was released in May 2014. It features appearances from Alicia Keys, Kendrick Lamar, Pharrell Williams, and Hans Zimmer.

On March 12, 2014, Columbia Records issued a press release announcing that "It's On Again" would be included on the soundtrack for The Amazing Spider-Man 2 (2014) and serve as the closing song for the film. The release included a statement from director Marc Webb, who described the process of selecting "a song that would be upbeat and exciting, but also contain a note of foreboding" to serve as the film's the closing theme and praised "It's On Again" as the "perfect end note." Keys also expressed her excitement at working with Kendrick Lamar, producer Pharrell Williams and film composer Hans Zimmer, the latter of whom scores the film. On March 31, "It's On Again" was uploaded to Keys' official Soundcloud page and impacted mainstream urban radio in the United States. The following day, it was released digitally as a single.

The songs was performed for the first time on television on The Tonight Show with Jimmy Fallon. The song was also performed at the film's premiere concert in New York City.

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