Isuwa (transcribed Išuwa and sometimes rendered Ishuwa) was the ancient Hittite name for one of its neighboring Anatolian kingdoms to the east, in an area which later became the Luwian Neo-Hittite state of Kammanu.
The land of Isuwa was situated in the upper Euphrates river region. The river valley was here surrounded by the Anti-Taurus Mountains. To the northeast of the river lay a vast plain stretching up to the Black Sea mountain range.
The plain had favourable climatic conditions due to the abundance of water from springs and rainfall. Irrigation of fields was possible without the need to build complex canals. The river valley was well suited for intensive agriculture, while livestock could be kept at the higher altitudes. The mountains possessed rich deposits of copper which were mined in antiquity.
The Isuwans left no written record of their own, and it is not clear which of the Anatolian peoples inhabited the land of Isuwa prior to the Luwians. They could have been Indo-Europeans like the Luwians, related to the Hittites to the west, Hattians, Hurrians from the south, or Urartians who lived east of Isuwa in the first millennium BC.
The area was one of the places where agriculture developed very early in the Neolithic period. Urban centres emerged in the upper Euphrates river valley around 3000 BC. The first states may have followed in the third millennium BC. The name Isuwa is not known until the literate Hittite period of the second millennium BC. Few literate sources from within Isuwa have been discovered and the primary source material comes from Hittite texts.
To the west of Isuwa lay the hostile kingdom of the Hittites. The Hittite king Hattusili I (c.1600 BC) is reported to have marched his army across the Euphrates river and destroyed the cities there. This corresponds with burnt destruction layers discovered by archaeologists at town sites in Isuwa at roughly this date.