Isradipine
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| Clinical data | |
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| Trade names | DynaCirc |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a693048 |
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| Routes of administration |
Oral |
| ATC code | |
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| Pharmacokinetic data | |
| Bioavailability | 15-24% |
| Protein binding | 95% |
| Metabolism | 100% Hepatic |
| Biological half-life | 8 hours |
| Excretion | 70% Renal, 30% Fecal |
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| CAS Number | |
| PubChem CID | |
| DrugBank | |
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| KEGG | |
| ChEMBL | |
| ECHA InfoCard | 100.158.721 |
| Chemical and physical data | |
| Formula | C19H21N3O5 |
| Molar mass | 371.387 g/mol |
| 3D model (Jmol) | |
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Isradipine (tradenames DynaCirc, Prescal) is a calcium channel blocker of the dihydropyridine class. It is usually prescribed for the treatment of high blood pressure in order to reduce the risk of stroke and heart attack.
Isradipine is given as either a 2.5 mg or 5 mg capsule.
Common side effects include:
-Dizziness
-Warmth, redness, or tingly feeling under your skin
-Headache
-Weakness, tired feeling
-Nausea, vomiting, diarrhea, upset stomach
-Skin rash or itching
Serious side effects include:
-Lightheadedness or fainting
-Shortness of breath, especially from minimal physical activity
-Swelling in the hands and feet
-Rapid and/or heavy heartbeat
-Chest pain
1. It is advised that those using Isradipine not take Anzemet (Dolasetron), as both agents can cause a dose-dependent PR interval and QRS complex prolongation.
2. Onmel/Sporanox (Itraconazole) exhibits a negative inotropic effect on the heart and thus could spur an additive effect when used concomitantly with Isradipine. Onmel/Sporanox also inhibits an important liver enzyme (CYP 450 3A4) which is needed to metabolize Isradipine and other Calcium Channel Blockers. This will increase plasma levels of Isradipine and could cause an unintentional overdose of the medication. Caution is advised when administering both agents together.
3. Zanaflex (Tizanidine) demonstrates anti-hypertensive effects and should be avoided in patients taking Isradipine due to the possibility of synergism between both medications.
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Wikipedia