Ishaq al-Mawsili (Arabic: إسحاق الموصلي) was a Persian musician of the Abbasid court at the time of Harun al-Rashid. He was born into family of musicians from Kufa in Iraq; his father Ibrahim al-Mawsili held the same position before him.
He was also the teacher of the influential Ziryab, and the contemporary of Mukhariq.