Al-Issawiya (Arabic: العيساوية) is an urban, Arab neighborhood in Jerusalem. It is located on Mount Scopus near Hadassah Medical Center.
A burial cave, with pottery dating to the Early Roman period (first century CE), has been found at Isawiya.
Isawiya, like the rest of Palestine, was incorporated into the Ottoman Empire in 1517, and in the 1560s the revenues of al-Isawiya were designated for the waqf of Hasseki Sultan Imaret in Jerusalem, established by Hasseki Hurrem Sultan (Roxelana), wife of Suleiman the Magnificent. In the 1596 tax registers it appeared as Isawiyya, in the Nahiya of Quds of the Liwa of Quds, with a population of 35 households and 3 bachelors, all Muslim. Taxes were paid for wheat, barley, olive trees, vineyards, fruit trees, goats and beehives.
In 1838 it was noted as "a small village".
An Ottoman village list from about 1870 found that Isawiya had a population of 178, (or 78), in 29 houses, though the population count included men, only.
In 1883, the Palestine Exploration Fund's Survey of Western Palestine described El Aisawiyeh as a "small village on the eastern slope of the chain of Olivet, with a spring to the south and a few olives round it."
In the 1922 census of Palestine, conducted by the British Mandate authorities, 'Isawiyeh had a population of 333, all Muslims, increasing in the 1931 census to a population of 558, 7 Christians and the rest Muslim, occupying 117 houses.