Isaac Spooner (c.1735–1816) was an English ironmaster, nail manufacturer and banker.
The son of Abraham Spooner and Anne Knight, he went into the family iron business based around a furnace at Aston, in the Birmingham area. In 1791 he founded a bank with Matthias Attwood the elder, known then as the Birmingham Bank, and in 1801 it opened a London branch, Spooner, Attwood & Holman. His views were evangelical and abolitionist.
Spooner owned an estate of over 2000 acres at Elmdon, and he completed Elmdon Hall, started by his father, in 1795. The bank Attwood, Spooner & Co. failed in 1865. The Hall was demolished in 1956.
Spooner married Barbara Gough, sister of Henry Gough-Calthorpe, 1st Baron Calthorpe. They had children including:
There were nine in all, with the unmarried Eliza; or ten. Richard is said to be the ninth child in an 1885 Life of Thomas Attwood.