Irene Asanina (died after 1354), was the Empress consort of John VI Kantakouzenos of the Byzantine Empire.
Asanina was a daughter of Andronikos Asen and his wife Tarchanaiotissa. Her paternal grandparents were Ivan Asen III of Bulgaria and Irene Palaiologina. Her maternal grandparents were protostrator Michael Doukas Glabas Tarchaneiotes and his wife Maria Doukaina Komnene Palaiologina Branaina.
The last names of her maternal grandmother indicate descent from the families Doukas, Komnenos and Palaiologos who each produced several Byzantine Emperors. Her last name however indicates being a member of the Branas family which produced military leaders, like Alexios Branas and Theodore Branas, but whose genealogy is poorly recorded.
Her paternal grandmother, Irene Palaiologina, was a daughter of Michael VIII Palaiologos and Theodora Palaiologina which makes Asanina a member of the extended Imperial family of her time.
Kantakouzenos was a trusted advisor of Andronikos III Palaiologos, grandson of Andronikos II and great-grandson of Michael VIII. Andronikos III died on 15 June 1341 and was succeeded by his eldest son John V Palaiologos, who was only nine-years-old and was placed under the regency of his mother Anna of Savoy. However Andronikos III had entrusted the administration of the empire to Kantakouzenos.
At about the same time, Stefan Uroš IV Dušan of Serbia launched an invasion of Northern Thrace. Kantakouzenos left Constantinople to try to restore order to the area. Anna took advantage of his absence to declare him an enemy of the state and to strip him of titles and fortune. But Kantakouzenos was still in control of part of the Byzantine army and, on 26 October 1341, he answered by proclaiming himself emperor at Didymoteicho. Irene joined him and was crowned Empress at his side. One of her first acts as Empress was to obtain the release of her two brothers, John and Manuel Asen, who had been imprisoned in Thrace since 1335 on a charge of treason.