Interdigital webbing is the presence of membranes of skin between the digits. Normally in mammals, webbing is present in the embryo but resorbed later in development, but in various mammal species it occasionally persists in adulthood. In humans, it can be found in those suffering from LEOPARD syndrome and from Aarskog-Scott syndrome.
Webbing between the digits of the hindfoot is also present in several mammals that spend part of their time in the water. Webbing accommodates movement in the water.
Interdigital webbing is not to be confused with syndactyly, which is a fusing of digits and occurs rarely in humans. Syndactyly specifically affecting feet occurs in birds (such as ducks), amphibians (such as frogs), and mammals (such as the kangaroo).
In oryzomyines, a mainly South American rodent group, the marsh rice rat, Pseudoryzomys simplex, and Sigmodontomys alfari all have small webs, which do not extend to the end of the proximal phalanges, whereas Amphinectomys savamis, Lundomys molitor and the members of the genera Holochilus and Nectomys have more expansive webbing, which extends beyond the proximal phalanges. Webbing apparently developed several times in oryzomyines and may also have been lost in some groups. Most ichthyomyines, an exclusively semiaquatic South and Central American rodent group, have small webbing, but members of the genus Rheomys have more expansive webs. Webbing is also present in the Australasian semiaquatic hydromyines (subfamily Murinae) of the genera Baiyankamys, Hydromys, and Crossomys; in the latter, it is most well-developed. The African semiaquatic rodents Colomys goslingi and Nilopegamys plumbeus, also members of the Murinae, lack interdigital webbing. Webbing is present in the hind feet of the coypu (Myocastor coypus) of South America, which is currently classified in its own family.